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MKP-2/DUSP4 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984226
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50-198-4226 100 μL
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Catalog No. 50-198-4226 Supplier Bioss Supplier No. BS1852R
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Rabbit Polyclonal Antibody

DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.

Specifications

Antigen MKP-2/DUSP4
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene DUSP4
Gene Accession No. Q13115
Gene Alias 2700078F24Rik; AI844617; BB104621; dual specificity phosphatase 4; Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; DUSP 4; Dusp4; DUSP-4; E130306H24Rik; HVH2; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP II; MKP2; Mkp-2; MKPII; serine/threonine specific protein phosphatase; TYP; VH1 homologous phosphatase 2; VH2
Gene Symbols DUSP4
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human MKP-2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1846
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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