Invitrogen™ MKP1/MKP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599519

Catalog No. PIPA599519

Description

Antibody detects endogenous levels of total MKP1/2.

There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs (ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain. MKP2 is expressed in a variety of tissues, and is localized in the nucleus. Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. E2F-1/MKP2 pathway mediates apoptosis under oxidative stress and that MKP2 suppresses tumor formation. MKP2 is a novel transcription target of p53 in mediating apoptosis by 10-bp palindrome motif (CTGGCGCCAG) in the MKP2 promoter.

Specifications

• Antigen: MKP1/MKP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DUSP1
• Gene Alias: 2700078F24Rik; 3CH134; 3CH134/CL100 PTPase; AI844617; BB104621; CL 100; CL100; dual specificity phosphatase 1; dual specificity phosphatase 4; dual specificity protein phosphatase 1; Dual specificity protein phosphatase 4; dual specificity protein phosphatase hVH1; Dual specificity protein phosphatase hVH2; DUSP 4; DUSP1; Dusp4; DUSP-4; E130306H24Rik; erp; HVH1; HVH2; MAP kinase phosphatase 1; MAP kinase phosphatase 2; MAP kinase phosphatase-1; mitogen-activated protein (MAP) kinase phosphatase-1; mitogen-activated protein kinase phosphatase 1; Mitogen-activated protein kinase phosphatase 2; mitogen-activated protein kinase phosphatase-1; MKP II; Mkp1; mkp-1; Mkp2; Mkp-2; MKPII; oxidative stress-inducible protein tyrosine phosphatase; protein tyrosine phosphatase non-receptor type 16; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase 3CH134; Protein-tyrosine phosphatase CL100; protein-tyrosine phosphatase ERP; Protein-tyrosine phosphatase non-receptor type 16; PTPN10; Ptpn16; serine/threonine specific protein phosphatase; TYP; U19515; VH1; VH1 homologous phosphatase 2; VH2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114856, 1843, 1846, 19252, 319520, 60587
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P28562, P28563, Q13115, Q62767, Q64623, Q8BFV3
• Gene Symbols: DUSP1, DUSP4
• Immunogen: A synthesized peptide derived from human DUSP1(Accession P28562), corresponding to amino acid residues L270-E320.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov