Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA599519

Invitrogen™ MKP1/MKP2 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA599519
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA599519 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA599519 Supplier Invitrogen™ Supplier No. PA599519
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MKP1/2.

There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs (ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain. MKP2 is expressed in a variety of tissues, and is localized in the nucleus. Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. E2F-1/MKP2 pathway mediates apoptosis under oxidative stress and that MKP2 suppresses tumor formation. MKP2 is a novel transcription target of p53 in mediating apoptosis by 10-bp palindrome motif (CTGGCGCCAG) in the MKP2 promoter.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MKP1/MKP2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DUSP1
Gene Accession No. P28562, P28563, Q13115, Q62767, Q64623, Q8BFV3
Gene Alias 2700078F24Rik; 3CH134; 3CH134/CL100 PTPase; AI844617; BB104621; CL 100; CL100; dual specificity phosphatase 1; dual specificity phosphatase 4; dual specificity protein phosphatase 1; Dual specificity protein phosphatase 4; dual specificity protein phosphatase hVH1; Dual specificity protein phosphatase hVH2; DUSP 4; DUSP1; Dusp4; DUSP-4; E130306H24Rik; erp; HVH1; HVH2; MAP kinase phosphatase 1; MAP kinase phosphatase 2; MAP kinase phosphatase-1; mitogen-activated protein (MAP) kinase phosphatase-1; mitogen-activated protein kinase phosphatase 1; Mitogen-activated protein kinase phosphatase 2; mitogen-activated protein kinase phosphatase-1; MKP II; Mkp1; mkp-1; Mkp2; Mkp-2; MKPII; oxidative stress-inducible protein tyrosine phosphatase; protein tyrosine phosphatase non-receptor type 16; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase 3CH134; Protein-tyrosine phosphatase CL100; protein-tyrosine phosphatase ERP; Protein-tyrosine phosphatase non-receptor type 16; PTPN10; Ptpn16; serine/threonine specific protein phosphatase; TYP; U19515; VH1; VH1 homologous phosphatase 2; VH2
Gene Symbols DUSP1, DUSP4
Host Species Rabbit
Immunogen A synthesized peptide derived from human DUSP1(Accession P28562), corresponding to amino acid residues L270-E320.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114856, 1843, 1846, 19252, 319520, 60587
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.