Invitrogen™ MKP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596197

Catalog No. PIPA596197

Description

Immunogen sequence: MVTMEELREM DCSVLKRLMN RDENGGGAGG SGSHGTLGLP SGGKCLLLDC RPFLAHSAGY ILGSVNVRCN TIVRRRAKGS VSLEQILPAE EEVRARLRSG LYSAVIVYDE RSPRAESLRE DSTVSLVVQA LRRNAERTDI CLLKGGYERF SSEYPEFCSK TKALAAIP; Positive Samples: COS-7, HeLa, A375; Cellular Location: Nucleus.

DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.

Specifications

• Antigen: MKP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DUSP4
• Gene Alias: 2700078F24Rik; AI844617; BB104621; dual specificity phosphatase 4; dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; DUSP 4; DUSP4; DUSP-4; E130306H24Rik; HVH2; MAP kinase phosphatase 2; mitogen-activated protein kinase phosphatase 2; MKP II; Mkp2; Mkp-2; MKPII; serine/threonine specific protein phosphatase; TYP; VH1 homologous phosphatase 2; VH2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1846
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.72 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q13115
• Gene Symbols: DUSP4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human DUSP4 (NP_0013851).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG