Invitrogen™ MKP3 Recombinant Rabbit Monoclonal Antibody (1V5L10)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535048

Catalog No. PIMA535048

Description

Immunogen sequence: ARGKNCGVLV HCLAGISRSV TVTVAYLMQK LNLSMNDAYD IVKMKKSNIS PNFNFMGQLL DFERTLGLSS PCDNRVPAQQ LYFTTPSNQN VYQVDSLQST.

DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.

Specifications

• Antigen: MKP3
• Classification: Recombinant Monoclonal
• Concentration: 2.5 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q16828, Q64346, Q9DBB1
• Gene Symbols: DUSP6
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 282-381 of human DUSP6 (Q16828).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 1V5L10
• Conjugate: Unconjugated
• Gene: DUSP6
• Gene Alias: 1300019I03Rik; dual specificity phosphatase 6; dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Dusp6; DUSP6-ALT; HH19; MAP kinase phosphatase 3; mitogen-activated protein kinase phosphatase 3; Mkp3; MKP-3; PYST1; serine/threonine specific protein phosphatase
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116663, 1848, 67603
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid