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Invitrogen™ MKP3 Polyclonal Antibody
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Catalog No. PIPA521570
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100 μL
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PIPA521570 100 μL
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Catalog No. PIPA521570 Supplier Invitrogen™ Supplier No. PA521570
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549. Predicted reactivity: Mouse (98%), Rat (99%), Zebrafish (92%), Xenopus laevis (96%), Pig (100%), Chicken (96%), Rhesus Monkey (100%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MKP3
Applications Western Blot
Classification Polyclonal
Concentration 0.91 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene DUSP6
Gene Accession No. Q16828
Gene Alias 1300019I03Rik; dual specificity phosphatase 6; dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Dusp6; DUSP6-ALT; HH19; MAP kinase phosphatase 3; mitogen-activated protein kinase phosphatase 3; Mkp3; MKP-3; PYST1; serine/threonine specific protein phosphatase
Gene Symbols DUSP6
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human DUSP6. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1848
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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