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Invitrogen™ MKP3 Polyclonal Antibody
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Catalog No. PIPA5120858
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PIPA5120858 100 μL
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Catalog No. PIPA5120858 Supplier Invitrogen™ Supplier No. PA5120858
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HT-29, 293T. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: TVTVAYLMQK LNLSMNDAYD IVKMKKSNIS PNFNFMGQLL DFERTLGLSS PCDNRVPAQQ LYFTTPSNQN VYQVDSLQST.

DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MKP3
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.60 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene DUSP6
Gene Accession No. Q16828, Q64346, Q9DBB1
Gene Alias 1300019I03Rik; dual specificity phosphatase 6; dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Dusp6; DUSP6-ALT; HH19; MAP kinase phosphatase 3; mitogen-activated protein kinase phosphatase 3; Mkp3; MKP-3; PYST1; serine/threonine specific protein phosphatase
Gene Symbols DUSP6
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence within amino acids 302-381 of human DUSP6 (NP_001937.2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116663, 1848, 67603
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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