Invitrogen™ MKP3 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142997

Catalog No. PIPA5142997

Description

Additional Information: This antibody is expected to recognize both reported isoforms (NP_001937.2; NP_073143.2). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.

Specifications

• Antigen: MKP3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DUSP6
• Gene Alias: 1300019I03Rik; dual specificity phosphatase 6; dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Dusp6; DUSP6-ALT; HH19; MAP kinase phosphatase 3; mitogen-activated protein kinase phosphatase 3; Mkp3; MKP-3; PYST1; serine/threonine specific protein phosphatase
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 100622968, 116663, 1848, 67603
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q16828, Q64346, Q9DBB1
• Gene Symbols: DUSP6
• Immunogen: Peptide with sequence C-PSNQNVYQVDSLQST (aa 367-381).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Pig
• Product Type: Antibody
• Isotype: IgG