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Tocris Bioscience™ ML 210
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Catalog No. 642910
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64-291-0 10 mg
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Catalog No. 64-291-0 Supplier Tocris Bioscience™ Supplier No. 6429/10
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Description

Selectively kills mutant HRAS-expressing cells

ML 210 is a glutathione peroxidase (GPX4) inhibitor. Kills mutant RAS-expressing cell lines (IC50 values are 71 and 272 nM for HRAS G12v mutant expressing cell lines BJeLR and BJeH-LT, respectively). Exhibits 4-fold selectivity for HRAS mutant-expressing cell lines. Induces ferroptosis in tumor initiation "persister" cells and drug-resistant tumor cells.

Specifications

Chemical Name or Material [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone
CAS 1360705-96-9
Quantity 10 mg
Molecular Formula C22H20Cl2N4O4
Formula Weight 475.32
Purity 98%
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