Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ ML 252

Tocris Bioscience™ ML 252
GREENER_CHOICE

Catalog No. 468710
Change view
Click to view available options
Quantity:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
46-871-0 10 mg
46-875-0 50 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Catalog No. 46-871-0 Supplier Tocris Bioscience™ Supplier No. 4687/10
Only null left
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Potent and selective KV7.2 inhibitor; brain penetrant

ML 252 is a potent and selective inhibitor of KV7.2 voltage-gated potassium channels (IC50 = 70 nM), which displays >40-fold selectivity for KV7.2 over KV7.1 channels (IC50 = 2.9 μM for KV7.1). ML 252 is the (S)-enantiomer, and is more potent than the (R)-enantiomer or racemic mixture (IC50 values are 944 and 160 nM, respectively). ML 252 displays selectivity for KV7.2 over a panel of >68 GPCRs, ion channels and transporters; inhibits melatonin MT1 receptor 60% at 10 μM. ML 252 is brain penetrant.

Specifications

Chemical Name or Material (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
CAS 1392494-64-2
Quantity 10 mg
Target Voltage-gated Potassium Channel Blockers
Molecular Formula C20H24N2O
Purity 0.98
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.