Tocris™ ML 297

Selective Kir3.1/3.2 (GIRK1/2) channel activator

Manufacturer: Tocris™ 5380/50

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Catalog No. 53-805-0

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For Research Use Only


    Specifications

    Product Type ML 297
    Inhibitors ML 297
    Purity >99
    Molecular Weight 328.32
    Quantity 50mg

    Selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.

    • Chemical Name: N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
    • Formula: C17H14F2N4O
    • CAS Number: 1443246-62-5
    • Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
    • Purity: >99

  • Description & Specifications

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