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Tocris Bioscience™ ML 299
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Catalog No. 48942
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48-942 2 mg
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Catalog No. 48-942 Supplier Tocris Bioscience™ Supplier No. 4894/2
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Description

Potent inhibitor of PLD1 and PLD2; CNS penetrant

ML 299 is a selective allosteric modulator and potent inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML 299 decreases invasive migration in glioblastoma cells and increases caspase 3/7 activity in serum-free conditions. ML 299 is non-cytotoxic, active in vivo and CNS penetrant.

Specifications

Chemical Name or Material 4-Bromo-N-[(1 S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5 ]dec-8-yl]-1-methylethyl]benzamide
CAS 1426916-00-8
Quantity 2 mg
Target Phospholipase Inhibitors
Molecular Formula C23H26BrFN4O2
Purity 0.98
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