Tocris™ ML 347

Potent and selective ALK1 and ALK2 inhibitor

Manufacturer: Tocris™ 4945/50

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Catalog No. 49-455-0

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For Research Use Only


    Product Type ML 347
    Inhibitors ML 347
    Purity >98
    Molecular Weight 352.39
    Quantity 50mg

    Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152nM).

    • Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
    • Formula: C22H16N4O
    • CAS Number: 1062368-49-3
    • Solubility: Soluble to 20mM in DMSO
    • Purity: >98

  • Description & Specifications

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