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Invitrogen™ MLH1 Recombinant Rabbit Monoclonal Antibody (8K1T2)

Catalog No. PIMA535590
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Quantity:
100 μL
Catalog No. Quantity
PIMA535590 100 μL
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Catalog No. PIMA535590

Supplier: Invitrogen™ MA535590

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: PGLAGPSGEM VKSTTSLTSS STSGSSDKVY AHQMVRTDSR EQKLDAFLQP LSKPLSSQPQ AIVTEDKTDI SSGRARQQDE EMLELPAPAE VAAKNQSLEG D.

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MLH1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 8K1T2
Concentration 0.69 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Mlh1
Gene Accession No. P40692, Q9JK91
Gene Alias 1110035C23Rik; AI317206; AI325952; AI561766; COCA2; colon cancer, nonpolyposis type 2; DNA mismatch repair protein Mlh1; DNA mismatch repair protein Mlh1-like protein; FCC2; hMLH1; HNPCC; HNPCC2; I79_014127; MGC5172; mismatch repair protein 1; MLH1; MLH-1; mutL homolog 1; mutL homolog 1 (E. coli); mutL homolog 1, colon cancer, nonpolyposis type 2; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); mutL protein homolog 1
Gene Symbols Mlh1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 350-450 of human MLH1 (NP_0002401).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17350, 4292
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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