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MLH1 Mouse anti-Human, Clone: OTI2D12, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF810280

Catalog No. 50-166-9986


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
Specifications

Specifications

MLH1
Monoclonal
Unconjugated
MLH1
Lyophilized
MLH1
Human recombit protein fragment corresponding to amino acids 299-527 of human MLH1 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI2D12
PBS with 8% trehalose and no preservative; pH 7.3
P40692
COCA2, FCC2, HNPCC, HNPCC2, hMLH1
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
4292
SDS
Documents
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