MLH1 Mouse anti-Human, Clone: UMAB191, lyophilized, UltraMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene UM800083CF

Catalog No. 50-168-5293

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Specifications

• Antigen: MLH1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MLH1
• Gene Alias: COCA2, FCC2, HNPCC, HNPCC2, hMLH1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4292
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin)
• Clone: UMAB191
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P40692
• Gene Symbols: MLH1
• Immunogen: Human recombit protein fragment corresponding to amino acids 299-527 of human MLH1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1