Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. Invitrogen™ MLH1 Recombinant Rabbit Monoclonal Antibody (BLR112H)

Invitrogen™ MLH1 Recombinant Rabbit Monoclonal Antibody (BLR112H)
GREENER_CHOICE

Catalog No. PIMA544415
Change view
Click to view available options
Quantity:
10 μL
100 μL
Catalog No. Quantity
PIMA544415 100 μL
PIMA544416 10 μL
2 options
This item is not returnable. View return policy

Catalog No. PIMA544415

Supplier: Invitrogen™ MA544415

Only null left
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MLH1
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR112H
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation BBS with 0.09% sodium azide; pH 8.2
Gene Mlh1
Gene Accession No. P40692
Gene Alias 1110035C23Rik; AI317206; AI325952; AI561766; COCA2; colon cancer, nonpolyposis type 2; DNA mismatch repair protein Mlh1; DNA mismatch repair protein Mlh1-like protein; FCC2; hMLH1; HNPCC; HNPCC2; I79_014127; MGC5172; mismatch repair protein 1; MLH1; MLH-1; mutL homolog 1; mutL homolog 1 (E. coli); mutL homolog 1, colon cancer, nonpolyposis type 2; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); mutL protein homolog 1
Gene Symbols Mlh1
Host Species Rabbit
Immunogen Peptide representing a region between residue 450 and 500 of Human DNA mismatch repair protein Mlh1.
Purification Method purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4292
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.