Invitrogen™ MLK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103309

Catalog No. PIPA5103309

Description

Antibody detects endogenous levels of total MAP3K9.

MAP3K9 (MLK1) is a serine/threonine protein kinase that functions in the MAP kinase pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Specifications

• Antigen: MLK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP3K9
• Gene Alias: E130314H24Rik; Map3k9; MEKK9; mitogen activated protein kinase kinase kinase 9; mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity); mixed-lineage kinase 1; MLK1; Prke1; RGD1562149
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 338372, 4293
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P80192, Q3U1V8
• Gene Symbols: MAP3K9
• Immunogen: A synthesized peptide derived from human MAP3K9(Accession P80192), corresponding to amino acid residues D1005-F1055.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov