Invitrogen™ MLK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110619

Catalog No. PIPA5110619

Description

Immunogen sequence: EGSPQRREKA NGLSTPSESP HFHLGLKSLV DGYKQWSSSA PNLVKGPRSS PALPGFTSLM EMEDEDSEGP GSGESRLQHS PSQSYLCIPF PRGEDGDGPS SDGIHEEPTP VNSATSTPQL TPTNSLKRGG.

MAP3K9 (MLK1) is a serine/threonine protein kinase that functions in the MAP kinase pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Specifications

• Antigen: MLK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP3K9
• Gene Alias: E130314H24Rik; Map3k9; MEKK9; mitogen activated protein kinase kinase kinase 9; mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity); mixed-lineage kinase 1; MLK1; Prke1; RGD1562149
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4293
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P80192
• Gene Symbols: MAP3K9
• Immunogen: Recombinant Protein corresonding to Human MLK1. Recombinant protein control fragment (Product #RP-88979).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov