MLL1 Recombinant Rabbit Monoclonal Antibody (BL-175-7E8), Bethyl Laboratories

Rabbit Recombit Monoclonal Antibody

Supplier:  Bethyl Laboratories, Inc A700010

Catalog No. 50-157-1273

Description

The recommended shelf life for this product is 1 year from date of receipt.

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of ′Lys-4′ of histone H3 (H3K4me) complex and acetylation of ′Lys-16′ of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on ′Thr-3′, less activity toward H3 dimethylated on ′Arg-8′ or ′Lys-9′, and has higher activity toward H3 acetylated on ′Lys-9′. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.

Specifications

• Antigen: MLL1
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene: KMT2A
• Gene Alias: ALL-1; Trithorax-like protein
• Host Species: Rabbit
• Purification Method: Ion-exchange chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4297
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Clone: BL-175-7E8
• Formulation: BBS with 0.09% sodium azide; pH 8.2
• Gene Accession No.: Q03164
• Gene Symbols: KMT2A
• Immunogen: Between 720 and 780
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG