MilliporeSigma™ MLL4 (MLL2), Rabbit, Unlabeled, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABE1867

Catalog No. ABE1867MI

Description

Histone-lysine N-methyltransferase 2D (EC 2.1.1.43; UniProt O14686; also known as ALL1-related protein, Lysine N-methyltransferase 2D, Myeloid/lymphoid or mixed-lineage leukemia protein 2, MLL2) is encoded by the KMT2D (also known as ALR, KABUK1, MLL2, MLL4) gene (Gene ID 8085) in human. MLL2 methylates Lys-4 of histone H3 to form H3K4me, which represents a specific tag for epigenetic transcriptional activation. MLL2 acts as coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. It is also a component of the ASCOM/Mll2/3 complex that plays an important role during development, particularly in lymphomagenesis. MLL2 is localized to the nucleus and is expressed in most embryonic and adult tissues, with the exception of the liver. Defects in MLL2 have been linked to Kabuki syndrome, a congenital mental retardation syndrome with additional features, including postnatal dwarfism, facial and bone deformities. Inactivating mutations in MLL2 gene have been linked to medulloblastoma. Ref.: Parsons, D.W., et al. (2011). Science 331, 435-439.

Specifications

• Antigen: MLL4 (MLL2)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KMT2D, ALR, KABUK1, MLL2, MLL4
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: This polyclonal antibody targets the region between the first and third coiled coil of MLL4 (MLL2) sequence.
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.

• Applications: ChIP Assay, Western Blot
• Concentration: Please refer to lot specific datasheet.
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene Accession No.: O14686
• Immunogen: His-tagged recombinant human MLL4 (MLL2) internal fragment from the region between the first and third coiled coil.
• Quantity: 100 μL
• Research Discipline: Epigenetics & Nuclear Function
• Gene ID (Entrez): NP_003473
• Target Species: Human

For Research Use Only. Not for use in diagnostic procedures.