Invitrogen™ MLLT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583183

Catalog No. PIPA583183

Description

Immunogen sequence: MVMPEGADTV SRPSPDYPML PTIPLSAFSD PKKTKPSHGS KDANKESSKT SKPHKVTKEH RERPRKDSES KSSSKELERE QAKSSKDTSR KLGEGRLPKE EKAPPPKAAF KEPKMALKE.

Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in chimeric genes that encode an N-terminal portion of Hrx fused to various partner proteins. Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to Hrx in t(11;19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.

Specifications

• Antigen: MLLT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MLLT1
• Gene Alias: AA407901; BAM11; CTC-503J8.6; ENL; ENL/MLL fusion; leukemia-associated protein MLLT1; LTG19; MLL/ENL fusion protein; MLLT1; MLLT1 super elongation complex subunit; MLLT1, super elongation complex subunit; MLLT1/MLL fusion; myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog; myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1; protein ENL; trithorax; YEATS domain-containing protein 1; YEATS1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4298
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.7 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q03111
• Gene Symbols: MLLT1
• Immunogen: Recombinant protein corresponding to Human MLLT1. Recombinant protein control fragment (Product #RP-102514).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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