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Invitrogen™ MLNR Polyclonal Antibody
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Catalog No. PIPA5106847
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100 μL
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PIPA5106847 100 μL
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Catalog No. PIPA5106847 Supplier Invitrogen™ Supplier No. PA5106847
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MTLR.

Motilin is a widely conserved 22 amino acid peptide hormone secreted from enterochromaffin cells of the gastrointestinal tract. Within the intestines, motilin potentiates intestinal motility by inducing contractions of the duodenum and through binding to surface receptors, designated GPR38 (G-protein coupled receptor 38). These motilin receptors are predominantly expressed in stomach, thyroid and bone marrow, and they are related to other G-protein coupled receptors located in the pituitary and hypothalamus, which mediate the signaling for growth hormone secretagogues. The gene encoding GPR38 is alternately spliced at the carboxy terminus to generate two related proteins that are designated GPR38-A and GPR38-B. Sequence comparisons of the two isoforms indicate that GPR38-A contains seven transmembrane domains while GPR38-B is predicted to contains only five transmembrane regions. Consistent with other G-protein coupled receptors, GPR38 activates phospholipase C signal transduction pathways and induces intracellular calcium mobilization after binding of motilin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MLNR
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MLNR
Gene Accession No. O43193
Gene Alias G protein-coupled receptor 38; GPR38; G-protein coupled receptor 38; MLNR; Motilin receptor; MTLR; MTLR1; thyrotropin releasing hormone receptor 2; Trhr2
Gene Symbols MLNR
Host Species Rabbit
Immunogen A synthesized peptide derived from human MLNR(Accession O43193), corresponding to amino acid residues I350-G400.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2862
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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