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MM 54, Tocris Bioscience™
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Catalog No. 59921
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Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent apelin receptor antagonist

Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.

Chemical Identifiers

CAS 1313027-43-8
Molecular Formula C70H121N29O15S4
Molecular Weight (g/mol) 1737.166
InChI Key BMJYNYGARUVBJU-CSRTWURCSA-N
PubChem CID 122705991
IUPAC Name (3S,6R,11R,14S,17S,20S)-6-[[(2S)-2-[[(2S)-6-amino-2-[[(3S,6R,11R,14S,17S,20S)-6-amino-3,17-bis[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-2,5,13,16,19-pentaoxo-8,9-dithia-1,4,12,15,18-pentazabicyclo[18.3.0]tricosane-11-carbonyl]amino]hexanoyl]
SMILES CC(C)CC1C(=O)NC(CSSCC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCN=C(N)N)N)C(=O)NC(CCCCN)C(=O)NC(CC3=CN=CN3)C(=O)NC4CSSCC(NC(=O)C(NC(=O)C(NC(=O)C5CCCN5C(=O)C(NC4=O)CCCN=C(N)N)CCCN=C(N)N)CC(C)C)C(=O)O

Specifications

Linear Formula C70H121N29O15S4
Quantity 1 mg
Solubility Information Soluble to 2mg/mL in water
Formula Weight 1737.15
Percent Purity 0.95

Safety and Handling

Recommended Storage Store at −20°C
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