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MME Monoclonal Antibody (OTI2A6), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA808300

Encompass_Preferred

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Catalog No. 50-168-2039


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Description

Description

CD10 (Common Acute Lymphocytic Leukemia Antigen ,CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt′s, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. CD10 is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. Further, CD10 is a 100 kDa type II transmembrane glycoprotein that exists in a single copy of greater than 45 kb. The 5′ untranslated region of the CD10 gene is alternatively spliced, resulting in four separate mRNA transcripts and the coding region is not affected by alternative splicing. Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie tooth Disease.
Specifications

Specifications

MME
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P08473
MME
Synthetic peptide between 488-505 amino acids from human CD10 (MME).
100 μL
Primary
Human
Antibody
IgG2b
Immunohistochemistry (Paraffin)
OTI2A6
Unconjugated
MME
CALLA, CD10, CMT2T, NEP, SCA43, SFE
Mouse
Affinity Chromatography
RUO
4311
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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