Invitrogen™ MMP12 Recombinant Rabbit Monoclonal Antibody (2G3)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538368

Catalog No. PIMA538368

Description

This antibody has been tested in direct-ELISA.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22. 3.

Specifications

• Antigen: MMP12
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol, 150 mM NaCl and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P39900
• Gene Symbols: Mmp12
• Immunogen: A synthesized peptide derived from human MMP12 (aa 450-464).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 2G3
• Conjugate: Unconjugated
• Gene: Mmp12
• Gene Alias: 3.4.24.65; AV378681; HME; Macrophage elastase; macrophage metalloelastase; macrophage-metalloelastase; matrix metallo protease; matrix metallopeptidase 12; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12; matrix metalloproteinase 12 (macrophage elastase); matrix metalloproteinase-12; ME; MGC138506; MME; Mmel; MMP; Mmp12; MMP-12; MMPs
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4321
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov