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Invitrogen™ MMP12 Polyclonal Antibody
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Catalog No. PIPA5120529
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100 μL
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PIPA5120529 100 μL
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Catalog No. PIPA5120529 Supplier Invitrogen™ Supplier No. PA5120529
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Description

Rabbit Polyclonal Antibody

Positive test controls include: A-549. The target is usually found in the following locations: Secreted, extracellular matrix, extracellular space. Immunogen sequence: DEFWTTHSGG TNLFLTAVHE IGHSLGLGHS SDPKAVMFPT YKYVDINTFR LSADDIRGIQ SLYGDPKENQ RLPNPDNSEP ALCDPNLSFD AVTTVGNKIF F.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22. 3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MMP12
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.73 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Mmp12
Gene Accession No. P34960, P39900, Q63341
Gene Alias 3.4.24.65; AV378681; HME; Macrophage elastase; macrophage metalloelastase; macrophage-metalloelastase; matrix metallo protease; matrix metallopeptidase 12; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12; matrix metalloproteinase 12 (macrophage elastase); matrix metalloproteinase-12; ME; MGC138506; MME; Mmel; MMP; Mmp12; MMP-12; MMPs
Gene Symbols Mmp12
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 200-300 of human MMP12 (NP_002417.2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117033, 17381, 4321
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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