MMP13 Monoclonal Antibody (LIPCO IID1), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA514247

Catalog No. PIMA514247

Description

MA5-14247 targets MMP-13 (Collagenase-3) (Rat) in IF, IP, and WB applications and shows reactivity with mouse and Rat samples. The MA5-14247 immunogen is rat MMP-13 from BC-1 cells.

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.

Specifications

• Antigen: MMP13
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P23097, P33435
• Gene Symbols: MMP13
• Immunogen: Rat MMP-13 from BC-1 cells
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
• Clone: LIPCO IID1
• Conjugate: Unconjugated
• Gene: MMP13
• Gene Alias: cb1034; Clg; CLG3; Collagenase; collagenase 3; collagenase 3a; matrix metalloproteinase 13a; collagenase-1; Collagenase3; Collagenase-3; collagenase-3 precursor; interstitial collagenase; MANDP1; matrix metallo protease; matrix metallopeptidase 13; matrix metallopeptidase 13 (collagenase 3); matrix metallopeptidase 13a; matrix metallopeptidase 13a (collagenase 3); matrix metalloproteinase 13; matrix metalloproteinase 13 (collagenase 3); matrix metalloproteinase-13; matrix metalloproteinase-13; MMP-13; interstitial protein; MMP; Mmp1; MMP13; MMP-13; mmp13 protein; mmp13a; MMPLg; MMPLh; MMPs; Procollagenase 3; UMRCASE; ZFMMP13
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 171052, 17386
• Content And Storage: 4° C
• Form: Liquid

Safety and Handling

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