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  6. MMP13 Monoclonal Antibody (OTI2A6), TrueMAB™, OriGene 

MMP13 Monoclonal Antibody (OTI2A6), TrueMAB™, OriGene
SDP

Catalog No. 501676771
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50-167-6771 100 μL
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Catalog No. 50-167-6771 Supplier OriGene Supplier No. TA506803
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Description

Mouse Monoclonal Antibody

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.

Specifications

Antigen MMP13
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI2A6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene MMP13
Gene Accession No. P45452
Gene Alias CLG3, MANDP1, MDST, MMP-13
Gene Symbols MMP13
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 104-471 of human MMP13 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4322
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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