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Invitrogen™ MMP13 Recombinant Rabbit Monoclonal Antibody (JF0893)
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Catalog No. PIMA542462
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100 μL
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PIMA542462 100 μL
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Catalog No. PIMA542462 Supplier Invitrogen™ Supplier No. MA542462
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: SW480 cell lysate, MCF-7 cell lysate, Hela, MCF-7, SW480, human lung carcinoma tissue, human breast tissue, human breast carcinoma tissue. Subcellular Location: Extracellular matrix, Secreted.

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MMP13
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone JF0893
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene MMP13
Gene Accession No. P45452
Gene Alias cb1034; Clg; CLG3; Collagenase; collagenase 3; collagenase 3a; matrix metalloproteinase 13a; collagenase-1; Collagenase3; Collagenase-3; collagenase-3 precursor; interstitial collagenase; MANDP1; matrix metallo protease; matrix metallopeptidase 13; matrix metallopeptidase 13 (collagenase 3); matrix metallopeptidase 13a; matrix metallopeptidase 13a (collagenase 3); matrix metalloproteinase 13; matrix metalloproteinase 13 (collagenase 3); matrix metalloproteinase-13; matrix metalloproteinase-13; MMP-13; interstitial protein; MMP; Mmp1; MMP13; MMP-13; mmp13 protein; mmp13a; MMPLg; MMPLh; MMPs; Procollagenase 3; UMRCASE; ZFMMP13
Gene Symbols MMP13
Host Species Rabbit
Immunogen Synthetic peptide within human MMP13 aa 390-430.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4322
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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