Invitrogen™ MMP19 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA513187

Catalog No. PIPA513187

Description

MMP19 Polyclonal Antibody for Western Blot, IHC (P), Flow

MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.

Specifications

• Antigen: MMP19
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MMP19
• Gene Alias: CODA; matrix metallo protease; matrix metallopeptidase 19; matrix metalloproteinase 19; matrix metalloproteinase RASI; Matrix metalloproteinase-18; matrix metalloproteinase-19; matrix metalloproteinase-beta19; MMP; MMP18; MMP-18; Mmp19; MMP-19; MMPs; Rasi; RASI-1
• Host Species: Rabbit
• Purification Method: Ammonium Sulfate Precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 4327
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q99542
• Gene Symbols: MMP19
• Immunogen: KLH conjugated synthetic peptide between 344-373 amino acids from the C-terminal region of human MMP19.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG