Invitrogen™ MMP19 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5111664

Catalog No. PIPA5111664

Description

Immunogen sequence: PVDYLSQYGY LQKPLEGSNN FKPEDITEAL RAFQEASELP VSGQLDDATR ARMRQPRCGL EDPFNQKTLK YLLLGRWRKK HLTFRILNL.

MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.

Specifications

• Antigen: MMP19
• Classification: Polyclonal
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q99542
• Gene Symbols: MMP19
• Immunogen: Recombinant Protein corresonding to Human MMP19. Recombinant protein control fragment (Product #RP-105511).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Gene: MMP19
• Gene Alias: CODA; matrix metallo protease; matrix metallopeptidase 19; matrix metalloproteinase 19; matrix metalloproteinase RASI; Matrix metalloproteinase-18; matrix metalloproteinase-19; matrix metalloproteinase-beta19; MMP; MMP18; MMP-18; Mmp19; MMP-19; MMPs; Rasi; RASI-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4327
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov