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Invitrogen™ MMP19 Polyclonal Antibody
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Catalog No. PIPA5111664
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PIPA5111664 100 μL
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Catalog No. PIPA5111664 Supplier Invitrogen™ Supplier No. PA5111664
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PVDYLSQYGY LQKPLEGSNN FKPEDITEAL RAFQEASELP VSGQLDDATR ARMRQPRCGL EDPFNQKTLK YLLLGRWRKK HLTFRILNL Highest antigen sequence indentity to the following orthologs: Rat - 87%, Mouse - 80%.

MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MMP19
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MMP19
Gene Accession No. Q99542
Gene Alias CODA; matrix metallo protease; matrix metallopeptidase 19; matrix metalloproteinase 19; matrix metalloproteinase RASI; Matrix metalloproteinase-18; matrix metalloproteinase-19; matrix metalloproteinase-beta19; MMP; MMP18; MMP-18; Mmp19; MMP-19; MMPs; Rasi; RASI-1
Gene Symbols MMP19
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human MMP19. Recombinant protein control fragment (Product #RP-105511).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4327
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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