MMP19 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-0654	100 μL

Catalog No. 50-198-0654 Supplier Bioss Supplier No. BS10058R

Description

Rabbit Polyclonal Antibody

MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.

Specifications

• Antigen: MMP19
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: MMP19
• Gene Accession No.: Q99542
• Gene Alias: CODA; matrix metallo protease; matrix metallopeptidase 19; matrix metalloproteinase 19; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; Matrix metalloproteinase-19; matrix metalloproteinase-beta19; MMP; MMP18; MMP-18; Mmp19; MMP-19; MMPs; Rasi; RASI-1
• Gene Symbols: MMP19
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human MMP19.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4327
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG