Invitrogen™ MMP2 Recombinant Rabbit Monoclonal Antibody (5I2G1)

Catalog No.	Quantity
FEMA551504	100 μL

Catalog No. FEMA551504 Supplier Invitrogen™ Supplier No. MA551504

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: ATTGACCTTG GCACCGGCCC CACCCCCACG CTGGGCCCTG TCACTCCTGA GATCTGCAAA CAGGACATTG TATTTGATGG CATCGCTCAG ATCCGTGGTG AGATCTTCTT CTTCAAGGAC CGGTTCATTT GGCGGACTGT GACGCCACGT GACAAGCCCA TGGGGCCCCT GCTGGTGGCC ACATTCTGGC CTGAGCTCCC GGAAAAGATT GATGCGGTAT ACGAGGCCCC ACAGGAGGAG AAGGCTGTGT TCTTTGCAGG GAATGAATAC TGGATCTACT CAGCCAGCAC CCTGGAGCGA GGGTACCCCA AGCCACTGAC CAGCCTGGGA CTGCCCCCTG ATGTCCAGCG AGTGGATGCC GCCTTTAACT GGAGCAAAAA CAAGAAGACA TACATCTTTG CTGGAGACAA ATTCTGGAGA TACAATGAGG TGAAGAAGAA AATGGATCCT GGCTTCCCCA AGCTCATCGC AGATGCCTGG AATGCCATCC CCGATAACCT GGATGCCGTC GTGGACCTGC AGGGCGGCGG TCACAGCTAC TTCTTCAAGG GTGCCTATTA CCTGAAGCTG GAGAACCAAA GTCTGAAGAG CGTGAAGTTT GGAAGCATCA AATCCGACTG GCTAGGCTGC.

MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.

Specifications

• Antigen: MMP2
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 5I2G1
• Concentration: 0.55 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene: MMP2
• Gene Accession No.: P08253, P33434, P33436
• Gene Alias: 72 kDa gelatinase; 72 kDa type IV collagenase; 72 kDa type IV collagenase isoform a preproprotein; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; CLG 4A; CLG4; CLG4A; Collagenase; collagenase type IV-A; endopeptidase; GelA; gelatinase A; Gelatinase alpha; Mat; matrix metallo protease; matrix metallopeptidase 2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloprotease 2; matrix metalloproteinase; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; MMP; MMP2; MMP-2; MMP-2 protein; MMP-II; MMPs; MONA; neutrophil gelatinase; PEX; prepro-72kDa matrix metalloproteinase; Progelatinase A; TBE1; TBE-1; wu:fa99h12; wu:fk89d01
• Gene Symbols: MMP2
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 451-660 of human MMP2(NP_004521.1).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 17390, 4313, 81686
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Format: Liquid
• Isotype: IgG