Invitrogen™ MMP24 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100202

Catalog No. PIPA5100202

Description

Antibody detects endogenous levels of total MMP24.

All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell-matrix interactions. MMPs are Zn (2+)-binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.

Specifications

• Antigen: MMP24
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MMP24
• Gene Alias: AU040325; matrix metallo protease; matrix metallopeptidase 24; matrix metallopeptidase 24 (membrane-inserted); matrix metalloproteinase 24; matrix metalloproteinase 24 (membrane-inserted); matrix metalloproteinase-21; Matrix metalloproteinase-24; membrane type 5-MMP; membrane-type 5 matrix metalloproteinase; membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase; MMP; Mmp21; MMP-21; Mmp24; MMP-24; MMP25; MMPs; MT5MMP; Mt5-mmp; MT-MMP 5; MTMMP5; MT-MMP5; Processed matrix metalloproteinase-24; RP4-614O4.10
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10893, 17391, 83513
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q99PW6, Q9R0S2, Q9Y5R2
• Gene Symbols: MMP24
• Immunogen: A synthesized peptide derived from human MMP24(Accession Q9Y5R2), corresponding to amino acid residues F442-K492.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov