Invitrogen™ MMP25 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109967

Catalog No. PIPA5109967

Description

Immunogen sequence: SPRPARLHRF WEGLPAQVRV VQAAYARHRD GRILLFSGPQ FWVFQDRQLE GGARPLTELG LPPGEEVDAV FSWPQNGKTY LVRGRQYWRY DEAAARPDPG YPRDLSLWEG APPSPDDVTV SNAGDTYFFK GAHYWRFPKN SIKTEPDAPQ PMGPNWLDCP APSSGPRAPR PPKATPVSET CDCQCELNQA A.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.

Specifications

• Antigen: MMP25
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mmp25
• Gene Alias: F730048C11Rik; Leukolysin; matrix metallo protease; matrix metallopeptidase 25; matrix metallopeptidase-like 1; matrix metalloproteinase 20; matrix metalloproteinase 25; matrix metalloproteinase-25; matrix metalloproteinase-like 1; membrane-type 6 matrix metalloproteinase; membrane-type matrix metalloproteinase 6; Membrane-type-6 matrix metalloproteinase; MMP; MMP 25; MMP20; MMP20A; Mmp25; MMP-25; MMPL1; MMPs; MT MMP 6; MT6 MMP; MT6MMP; MT6-MMP; MT-MMP 6; MTMMP6; MT-MMP6
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 240047, 302963, 64386
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.05 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q3U435, Q9NPA2
• Gene Symbols: Mmp25
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 350-540 of human MMP25 (NP_0719131).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov