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Invitrogen™ MMP25 Polyclonal Antibody
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Catalog No. PIPA5102679
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100 μL
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PIPA5102679 100 μL
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Catalog No. PIPA5102679 Supplier Invitrogen™ Supplier No. PA5102679
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MMP25.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MMP25
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Mmp25
Gene Accession No. Q3U435, Q9NPA2
Gene Alias F730048C11Rik; Leukolysin; matrix metallo protease; matrix metallopeptidase 25; matrix metallopeptidase-like 1; matrix metalloproteinase 20; matrix metalloproteinase 25; matrix metalloproteinase-25; matrix metalloproteinase-like 1; membrane-type 6 matrix metalloproteinase; membrane-type matrix metalloproteinase 6; Membrane-type-6 matrix metalloproteinase; MMP; MMP 25; MMP20; MMP20A; Mmp25; MMP-25; MMPL1; MMPs; MT MMP 6; MT6 MMP; MT6MMP; MT6-MMP; MT-MMP 6; MTMMP6; MT-MMP6
Gene Symbols Mmp25
Host Species Rabbit
Immunogen A synthesized peptide derived from human MMP25(Accession Q9NPA2), corresponding to amino acid residues G222-R272.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 240047, 302963, 64386
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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