Invitrogen™ MMP28 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550237

Catalog No. PA550237

Description

The antibody detects endogenous levels of total MMP28 protein.

Epilysin, also known as matrix metalloproteinase-28 (MMP-28), is a secreted protein that belongs to the peptidase M10A family. Matrix metalloproteinase proteins are responsible for the breakdown of the extracellular matrix which is important for normal physiological processes such as tissue remodeling, reproduction and embryonic development. Epilysin is produced by proliferating keratinocytes and is responsible for mediating the degradation of casein. Its expression is upregulated in response to injury of the skin suggesting that Epilysin may be involved in tissue repair and homeostasis. In addition, Epilysin may function predominantly in the nervous system. Incubation of Epilysin with rat embryonic brain tissue results in the degradation of myelin proteins. In Xenopus, Epilysin localizes to nerves and is upregulated during neurulation. This suggests that Epilysin plays an evolutionarily conserved role in neural development and may be involved in modulating the axonal-glial extracellular environment.

Specifications

• Antigen: MMP28
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MMP28
• Gene Alias: D130023P12; Epilysin; matrix metallo protease; matrix metallopeptidase 28; matrix metallopeptidase 28 (epilysin); matrix metalloprotease MMP25; matrix metalloproteinase 28 (epilysin); matrix metalloproteinase-28; MM28; MMP; MMP25; MMP-25; Mmp28; MMP-28; MMPs; PRO4339; UNQ1893; UNQ1893/PRO4339
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 118453, 79148
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.6 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9H239
• Gene Symbols: MMP28
• Immunogen: Fusion protein corresponding to residues near the C terminal of human matrix metallopeptidase 28.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG