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Invitrogen™ MMRN1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA557392
Description
Immunogen sequence: RHNLLRNEVQ GRDDALERRI NEYALEMEDG LNKTMTIINN AIDFIQDNYA LKETLSTIKD NSEIHHKCTS DMETILTFIP QFHRLND Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 63%.
Multimerin-1, also known as MMRN1, EMILIN-4 or ECM (endothelial cell multimerin), is a 1,228 amino acid secreted protein that contains one C1q domain, one EMI domain and one EGF-like domain. Synthesized in megakaryocytes and endothelial cells and present in liver, lung and placenta, Multimerin-1 exists as a multimeric structure composed of varying disulfide-linked multimers and functions as a carrier protein for platelet factors (specifically platelet factor V), playing a role in the stabilization and storage of factor V in platelets. In addition, Multimerin-1 acts as a ligand for select Integrins and may participate in extracellular matrix adhesion. Defects in the gene encoding Multimerin-1 that lead to Multimerin-1 deficiency are associated with autosomal dominant bleeding disorders due to platelet factor malfunction. Multiple isoforms of Multimerin-1 exist due to alternative splicing events.
Specifications
MMRN1 | |
Polyclonal | |
Unconjugated | |
MMRN1 | |
155 kDa platelet multimerin; 4921530G03Rik; ECM; Elastin microfibril interface located protein 4; elastin microfibril interfacer 4; EMILIN4; EMILIN-4; Endothelial cell multimerin; glycoprotein Ia*; GPIa*; MMRN; mmrn1; multimerin 1; multimerin-1; p155; p-155; Platelet glycoprotein Ia* | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
22915 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Immunocytochemistry | |
0.2 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q13201 | |
MMRN1 | |
Recombinant protein corresponding to Human MMRN1. Recombinant protein control fragment (Product #RP-96663). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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