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Invitrogen™ MMRN1 Polyclonal Antibody
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Catalog No. PIPA576977
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100 μL
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PIPA576977 100 μL
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Catalog No. PIPA576977 Supplier Invitrogen™ Supplier No. PA576977
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Multimerin-1, also known as MMRN1, EMILIN-4 or ECM (endothelial cell multimerin), is a 1,228 amino acid secreted protein that contains one C1q domain, one EMI domain and one EGF-like domain. Synthesized in megakaryocytes and endothelial cells and present in liver, lung and placenta, Multimerin-1 exists as a multimeric structure composed of varying disulfide-linked multimers and functions as a carrier protein for platelet factors (specifically platelet factor V), playing a role in the stabilization and storage of factor V in platelets. In addition, Multimerin-1 acts as a ligand for select Integrins and may participate in extracellular matrix adhesion. Defects in the gene encoding Multimerin-1 that lead to Multimerin-1 deficiency are associated with autosomal dominant bleeding disorders due to platelet factor malfunction. Multiple isoforms of Multimerin-1 exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MMRN1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MMRN1
Gene Accession No. B2RPV6, Q13201
Gene Alias 155 kDa platelet multimerin; 4921530G03Rik; ECM; Elastin microfibril interface located protein 4; elastin microfibril interfacer 4; EMILIN4; EMILIN-4; Endothelial cell multimerin; glycoprotein Ia*; GPIa*; MMRN; mmrn1; multimerin 1; multimerin-1; p155; p-155; Platelet glycoprotein Ia*
Gene Symbols MMRN1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1083-1228 of human MMRN1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22915, 70945
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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