MMS19 Mouse anti-Human, Mouse, Rat, Clone: 2H6D8, Proteintech

Catalog No.	Quantity
50-173-6488	150 μL

Catalog No. 50-173-6488 Supplier Proteintech Group Inc Supplier No. 660491IG150UL

Description

Mouse Monoclonal Antibody

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Specifications

• Antigen: MMS19
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 2H6D8
• Concentration: 0.98 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: MMS19
• Gene Accession No.: Q96T76, Q9D071
• Gene Alias: hMMS19, MET18, MET18 homolog, MMS19, MMS19 like protein, MMS19L
• Gene Symbols: Mms19
• Host Species: Mouse
• Immunogen: MMS19 Fusion Protein Ag8960
• Purification Method: Protein A
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 171124, 64210, 72199
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b