Invitrogen™ MMS19 Polyclonal Antibody

Catalog No.	Quantity
PIPA584093	100 μL

Catalog No. PIPA584093 Supplier Invitrogen™ Supplier No. PA584093

Description

Rabbit Polyclonal Antibody

Immunogen sequence: LVFMALTDPS TQLQLVGIRT LTVLGAQPDL LSYEDLELAV GHLYRLSFLK EDSQSCRVAA LEASGTLAAL YPVAFSSHLV PKLA Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 88%.

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Specifications

• Antigen: MMS19
• Applications: Immunocytochemistry, Immunofluorescence
• Classification: Polyclonal
• Concentration: 0.05 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: MMS19
• Gene Accession No.: Q96T76
• Gene Alias: 2410001K24Rik; 2610042O15Rik; AI316855; C79368; C86341; hMMS19; homolog of yeast MMS19; incisor protein; MET18; MET18 homolog; Mms19; MMS19 (MET18 S. cerevisiae); MMS19 cytosolic iron-sulfur assembly component; MMS19 homolog, cytosolic iron-sulfur assembly component; MMS19 nucleotide excision repair homolog; MMS19 nucleotide excision repair homolog (S. cerevisiae); MMS19 nucleotide excision repair protein homolog; MMS19 nucleotide excision repair-like; Mms19l; MMS19-like (MET18 homolog, S. cerevisiae); MMS19-like protein
• Gene Symbols: MMS19
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human MMS19. Recombinant protein control fragment (Product #RP-106363).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 64210
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG