MMS19 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA549097

Catalog No. PA549097

Description

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Specifications

• Antigen: MMS19
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q96T76
• Gene Symbols: MMS19
• Immunogen: KLH conjugated synthetic peptide between 411-437 amino acids from the Central region of human MMS19.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: MMS19
• Gene Alias: MMS19 nucleotide excision repair protein homolog, hMMS19, MET18 homolog, MMS19-like protein, MMS19, MMS19L
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64210
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid