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Invitrogen™ MMS2 Polyclonal Antibody
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Catalog No. PIPA5100617
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100 μL
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PIPA5100617 100 μL
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Catalog No. PIPA5100617 Supplier Invitrogen™ Supplier No. PA5100617
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MMS2.

The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains (4,5) UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MMS2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene UBE2V2
Gene Accession No. Q15819, Q7M767, Q9D2M8
Gene Alias 1 alpha,25-dihydroxyvitamin D3-inducible; 1110021H13Rik; 4632410D19Rik; 5730524P06Rik; 6820402M05; AI848315; C81524; DDVit 1; DDVIT1; DDVit-1; EDAF-1; EDPF1; EDPF-1; enterocyte differentiation promoting factor; enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; enterocyte differentiation-promoting factor 1; meth; methyl methanesulfonate sensitive 2; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of; Mms2; MMS2 homolog; ubc-like protein MMS2; UBE2V2; ubiquitin conjugating enzyme E2 V2; ubiquitin conjugating enzyme E2 variant 2; ubiquitin-conjugating enzyme E2 variant 2; ubiquitin-conjugating enzyme E2v2; ubiquitin-conjugating enzyme variant MMS2; UEV2; UEV-2; vitamin D3-inducible protein
Gene Symbols UBE2V2
Host Species Rabbit
Immunogen A synthesized peptide derived from human UBE2V2(Accession Q15819), corresponding to amino acid residues V67-V117.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 287927, 70620, 7336
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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