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  5. Tocris Bioscience™ MO-I-500

Tocris Bioscience™ MO-I-500
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Catalog No. 687110
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68-711-0 10 mg
68-715-0 50 mg
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Catalog No. 68-711-0 Supplier Tocris Bioscience™ Supplier No. 6871/10
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Description

FTO inhibitor; anticonvulsant

MO-I-500 is a FTO inhibitor (IC50 = 8.7 μM for purified FTO in vitro), which increases N6-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.

Specifications

Chemical Name or Material N-[5-(4-Chlorophenyl)-3,4-dihydroxy-2-furanyl]ethanesulfonamide
CAS 1585219-04-0
Quantity 10 mg
Target Other Oxidase/Oxygenase Compounds
Molecular Formula C12H12ClNO5S
Purity 0.98
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