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Invitrogen™ Dextran, SNARF™-1, 70,000 MW, Anionic

Catalog No. D3304
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D3304 5 mg
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Catalog No. D3304 Supplier Invitrogen™ Supplier No. D3304
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Description

Rigorous methods for removing as much unconjugated dye as practical, followed by assay of dextran conjugates by thin-layer chromatography to help ensure absence of low molecular weight contaminants

Labeled dextrans are hydrophilic polysaccharides most commonly used in microscopy studies to monitor cell division, track the movement of live cells, and to report the hydrodynamic properties of the cytoplasmic matrix. The labeled dextran is commonly introduced into the cells via microinjection. Dextrans are hydrophilic polysaccharides characterized by their moderate-to-high molecular weight, good water solubility, and low toxicity. They also generally exhibit low immunogeniticy. Dextrans are biologically inert due to their uncommon poly-(α-D-1,6-glucose) linkages, which render them resistant to cleavage by most endogenous cellular glycosidases.

  • Succinimidyl coupling of dyes to dextran molecule, which, in most cases, results in neutral or anionic dextran
  • Reaction used to produce Rhodamine Green™ and Alexa Fluor™ 488 dextrans results in final product being neutral, anionic, or cationic
  • Suitable for neuronal tracing (anterograde and retrograde) in live cells
  • Cell lineage tracing in live cells
  • Examines intercellular communications (e.g., in gap junctions, during wound healing, and during embryonic development)
  • Investigates vascular permeability and blood-brain barrier integrity
  • Monitors acidification (some dextran-dye conjugates are pH-sensitive)
  • Studies hydrodynamic properties of cytoplasmic matrix

Cell Analysis, Cell Metabolism, Cell Viability, Proliferation and Function, Ionic Homeostasis and Signaling, pH Detection

Order Info

Shipping Condition: Room temperature

TRUSTED_SUSTAINABILITY

Specifications

Content And Storage Store in freezer -5°C to -30°C and protect from light.
Detection Method Fluorescence
For Use With (Equipment) Confocal Microscope, Microplate Reader, Flow Cytometer
Product Type Dextran
Dye Type pH Indicator
Product Line SNARF
Quantity 5 mg
Shipping Condition Room Temperature

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures.

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