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Invitrogen™ MORF Monoclonal Antibody (8C8D12)
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Catalog No. PIMA538548
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100 μg
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Catalog No. Quantity
PIMA538548 100 μg
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Catalog No. PIMA538548 Supplier Invitrogen™ Supplier No. MA538548
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Description

Mouse Monoclonal Antibody

This antibody has been tested in indirect ELISA.

MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and Tip60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. Tip60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MORF
Applications ELISA, Western Blot
Classification Monoclonal
Clone 8C8D12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene KAT6B
Gene Accession No. Q8WYB5
Gene Alias AI507552; B130044K16Rik; GTPTS; histone acetyltransferase KAT6B; histone acetyltransferase MORF; histone acetyltransferase MOZ2; histone acetyltransferase MYST4; histone acetyltransferase querkopf; K(lysine) acetyltransferase 6B; Kat6b; KIAA0383; lysine acetyltransferase 6B; mKIAA0383; monocytic leukemia; monocytic leukemia zinc finger protein-related factor; MORF; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MOZ2; MOZ-related factor; MYST histone acetyltransferase (monocytic leukemia) 4; MYST histone acetyltransferase monocytic leukemia 4; Myst4; MYST-4; protein querkopf; qkf; querkopf; SAS2; TIP60 protein 4; ZC2HC6B
Gene Symbols KAT6B
Host Species Mouse
Immunogen Purified recombinant fragment of human KAT6B (aa: 1186-1318) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23522
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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