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Invitrogen™ MORF Polyclonal Antibody
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Catalog No. PIPA5103344
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PIPA5103344 100 μL
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Catalog No. PIPA5103344 Supplier Invitrogen™ Supplier No. PA5103344
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MYST4.

MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and Tip60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. Tip60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MORF
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene KAT6B
Gene Accession No. Q8BRB7, Q8WYB5
Gene Alias AI507552; B130044K16Rik; GTPTS; histone acetyltransferase KAT6B; histone acetyltransferase MORF; histone acetyltransferase MOZ2; histone acetyltransferase MYST4; histone acetyltransferase querkopf; K(lysine) acetyltransferase 6B; Kat6b; KIAA0383; lysine acetyltransferase 6B; mKIAA0383; monocytic leukemia; monocytic leukemia zinc finger protein-related factor; MORF; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MOZ2; MOZ-related factor; MYST histone acetyltransferase (monocytic leukemia) 4; MYST histone acetyltransferase monocytic leukemia 4; Myst4; MYST-4; protein querkopf; qkf; querkopf; SAS2; TIP60 protein 4; ZC2HC6B
Gene Symbols KAT6B
Host Species Rabbit
Immunogen A synthesized peptide derived from human KAT6B(Accession Q8WYB5), corresponding to amino acid residues Y2033-R2073.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23522, 54169
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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