ABCC1, Mouse, Clone: QCRL-4, Abnova™

Mouse monoclonal antibody raised against native ABCC1.

Supplier:  Abnova Corporation MAB5158

Catalog No. 89-112-151

Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq

Specifications

• Antigen: ABCC1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Flow Cytometry (1:20-1:40) Dot Blot (1:10000) The optimal working dilution should be determined by the end user.
• Gene: ABCC1
• Gene Symbols: ABCC1
• Immunogen: Native human small cell lung cancer cell line H69AR.
• Regulatory Status: RUO
• Gene ID (Entrez): 4363
• Target Species: Human, Monkey, Mouse, Rat
• Form: Liquid

• Applications: Dot Blot, Flow Cytometry, Immunocytochemistry, Immunoprecipitation
• Clone: QCRL-4
• Description: Mouse monoclonal antibody raised against native ABCC1.
• Formulation: In PBS (0.7% BSA, 0.09% sodium azide)
• Gene Alias: ABC29/ABCC/DKFZp686N04233/DKFZp781G125/GS-X/MRP/MRP1
• Host Species: Mouse
• Quantity: 1 mL
• Primary or Secondary: Primary
• Test Specificity: QCRL-4 reacts with a conformation-dependent internal epitope of MRP1, a 190 KDa trans-membrane phosphoglycoprotein overexpressed in various human multidrug resistant tumor cell lines. QCRL-4 inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles and its epitope has been localized to the second nucleotide binding domain of MRP1 between amino acids 1294 and 1531. QCRL-4 does not cross-react with human MDR1 and MDR3 gene products.
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1