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ABCC2, Mouse, Clone: M2II-12, Abnova™

Catalog No. 89111386 Shop All Abnova Corporation Products
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89-111-386 500 μL
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Catalog No. 89-111-386 Supplier Abnova Corporation Supplier No. MAB3383
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Description

Mouse monoclonal antibody raised against partial recombinant ABCC2.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq

Specifications

Antigen ABCC2
Applications Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Classification Monoclonal
Clone M2II-12
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against partial recombinant ABCC2.
Dilution Western Blot (1:20-50) Immunohistochemistry (Frozen sections) (1:20) Immunocytochemistry (1:20-1:50) The optimal working dilution should be determined by the end user.
Formulation In serum-free cell culture supernatant (0.09% sodium azide, 0.7% BSA)
Gene ABCC2
Gene Alias ABC30/CMOAT/DJS/KIAA1010/MRP2/cMRP
Gene Symbols ABCC2
Host Species Mouse
Immunogen Recombinant fusion protein corresponding to amino acids 860-950 of human ABCC2.
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1244
Test Specificity Reacts with an internal epitope of human cMOAT/MRP2. Does not cross-react with human MDR1, MRP1, MRP3, and MRP5 gene products.
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG2a
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