ABCC8, Mouse, Clone: 3G5, Abnova™

Catalog No.	Quantity
89-105-539	200 μL

Catalog No. 89-105-539 Supplier Abnova Corporation Supplier No. H00006833M01A

Description

Mouse monoclonal antibody raised against a partial recombinant ABCC8.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with noninsulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq

Sequence: SEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTM

Specifications

• Antigen: ABCC8
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 3G5
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant ABCC8.
• Formulation: ascites with no preservative
• Gene: ABCC8
• Gene Accession No.: NM_000352
• Gene Alias: ABC36/HHF1/HI/HRINS/MRP8/PHHI/SUR/SUR1/TNDM2
• Gene Symbols: ABCC8
• Host Species: Mouse
• Immunogen: ABCC8 (NP_000343,611 a.a. ∽ 710 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6833
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Ascites
• Isotype: IgG2a κ